The impact of self-care behaviour on health-related quality of life across functional dependency phenotipes: insights from a real-world cohort of 1120 patients with chronic heart failure

Abstract Background Poor self-care is associated with higher risk in heart failure (HF). Self-care may influence patient-reported outcomes (PROMs) such as health-realted quality of life (QoL). Functional and instrumental autonomy are determinants QoL. Literature has shown and/or functional dependency worse Purpose Describe the effect on QoL across to different levels explore potencial interaction between autonomy. Methods 1120 patients chronic HF from DAMOCLES study were analyzed. We used modified European Heart Failure Behavior Scale 9-item version (EHFSCBS-9) measure self-care, scores inverted. To assess QoL, we Minnesota Living Questionnaire (MLHFQ). for basic activities daily living (BADL) was evaluated using Barthel index (BI). Dependency (IA) Lawton Brody questionnaire (LBQ). Regarding dependency, grouped 3 phenotypes: independent (normal BI LBQ, phenotype 1), IA (abnormal 2) BADL ± abnormal LBT, 3). General linear models (GLM) constructed phenotypes poor (defined EHFSCBS-9 ≤lower tertile) adjusted MLHFQ obtain estimated marginal means self-care. All by severity. Results Mean age 72±11 years, 43% women mean LVEF 45±17%. 45±24. 69±28. There a significant inverse correlation EHFScBS-9 (r=−0.158; p-value <0.0001). Unadjusted consistenly (51.5±21.3) compared 2 (41.8±25.4, p-value<0.001) or 1 (41.6±25.6, <0.001). In GLM, global (F=15.7; <0.001) an predictor MLHFQ. Interaction term not significantly (F=0.297; = 0.743; Figure 1): gap terms strata observed phenotypes. Estimated stratified according displayed Table 1. 3, lower preserved differences present but significant. Conclusions behaviour health-related regardless level patient's Better better particularly dependendecy BADL. Impact attenuated normal Funding Acknowledgement Type funding sources: None.